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Studies Indicate Vitamin K2 May Have a Positive Effect on Cardiovascular Health and Osteoporosis

Vitamin K has long been recognized for its role in protein biosynthesis for the blood coagulation process. However, research now indicates that Vitamin K plays a vital part in a variety of complex physiological functions within the body. More specifically, Vitamin K2, the menaquinones, has been shown to support bone and soft tissue health while promoting healthy brain function and cardiovascular support.

The Vitamin K group of vitamins includes K1 and K2. Vitamin K1 or phylloquinone, is produced by plants and is commonly found in green vegetables and herbs. Although Vitamin K1 is readily available in plant-based foods and offers adequate blood clotting support, there are a variety health related issues that Vitamin K1 does not sufficiently support but are a growing problem. This is where supplementation of Vitamin K2 MK-7 becomes important in getting the optimum quality and quantity of Vitamin K2 in order to get the necessary nutrients needed to support health related issues.

Vegetables High in Vitamin K1

  • Kale
  • Dandelion Greens
  • Collard Greens
  • Spinach
  • Brussel Sprouts
  • Broccoli

Herbs High in Vitamin K1

  • Basil
  • Sage
  • Thyme/li>
herbs high in vitamin k1
Studies show high doses of Vitamin K2, MK-7 may address the following health issues:

  • Cardiovascular Health*
  • Brain Function*
  • Osteoporosis*
  • Arterial Calcification*
This is where the Vitamin K2 comes into place and more specifically Vitamin K2, MK-7, which is the optimum quality K2. Vitamin K2, the menaquinones is divided into short-chain menaquinones (MK-4) and long-chain menaquinones (MK-7, MK-8 and MK-9). Vitamin K2 is originally sourced from bacteria and is shown to be most effective with tissue that occurs outside of the liver such as bone, cartilage and vasculature. Vitamin K2 and Vitamin K1 are very different and cannot be obtained from the same foods. Whereas an individual can get Vitamin K1 from leafy green vegetables and herbs, Vitamin K2 is derived in its most potent form from fermented soybeans.

Although the structure of K vitamins is very similar in the sense that they share a quinone ring, they differ in the menaquinone chain, which signifies the specific tissues. So, MK-4 has four isoprene units that are attached to the quinone ring whereas MK-7 has seven isoprene units that are attached to the quinone ring. Even though it is a matter of a few isoprene units that separate these two forms of Vitamin K2, it is important to know that MK-4 and MK-7 function very differently within the body.

optimum-k2-diagram
Similar to Vitamin K1, Vitamin MK-4 has been shown beneficial in the blood coagulation process. Small traces of Vitamin K2 MK-4 are found in both meat and eggs. Vitamin K2 MK-4 (synthetic) differs from MK-7 (natural) in that it has a minimal half-life of merely an hour or so compared with MK-7, which stays in the body longer (few days), which increases its likelihood of consistent blood level maintenance.

The MK-7 form of Vitamin K2 is derived from the extract of fermented soybeans. Although many people in Japan consume fermented soybeans, the slimy and smelly taste and texture of them often make it too harsh and unpleasant to consume which is why getting the adequate amount of MK-7 is much easier and convenient as a dietary supplement. However, when considering a Vitamin K2, MK-7 supplement, it is important to make sure the MK-7 is derived from fermented soybeans in a Non-GMO form.

Vitamin K Deficiency

Vitamin K deficiency has been associated with the long-term use of antibiotics and anticoagulant drugs such as warfarin as well as decrease in green vegetable consumption. One of the biggest factors associated with anticoagulant drug use is arterial calcification, which in turn has been linked to several other health-related issues such as high blood pressure and thickening of ventricular walls.

Vitamin K deficiency has been more prevalent today than ever before since the Western diet is heavily lacking sufficient amounts of leafy green vegetables, which offer a significant source of Vitamin K1, a vital part of the blood coagulation process. What was once a staple food loaded with necessary nutrients has now become an after thought as more and more foods turn to packaged and processed to fit the fast paced lifestyles of people today. Since fewer greens are being consumed, health issues related to Vitamin K deficiency are on the rise such as cardiovascular disease, reduction of bone mineral density and decline in active osteocalcin, which increases the likelihood of fragile bones and fractures.

Vitamin K Side Effects and Interactions

In healthy individuals, research has not reported any side effects, adverse reactions or known toxicity as a result of large doses of Vitamin K2. However, individuals on anticoagulants such as warfarin should consult their healthcare professional before adding a Vitamin K2 supplement to their daily regimen.

References:

  1. Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203:489-493.
  2. Booth SL, Suttie JW. Dietary intake and adequacy of vitamin K. J Nutr. 1998;128(5):785-788.
  3. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134(11):3100-5.
  4. Hypotension associated with menaquinone Am J Health Syst Pharm 2012 69: 1307-1309.
  5. Iwamoto J, Takeda T, Sato Y. Effects of vitamin K2 on osteoporosis. Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. 2004;10(21):2557-76.
  6. Kaneki et al, “Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk.” Nutrition 2001, 17(4): 315-21.
  7. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007;18(7):963-72. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1915640/
  8. Vitamin K: Uses, Side Effects, Interactions and Warnings. Natural Medicines Comprehensive Database Consumer Version. Therapeutic Research Faculty, 2009. www.webmd.com
  9. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932-43.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Can Enzyme Deficiency Make You Tired?

Sirah Dubois, July 27, 2011. LIVESTRONG.COM

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Innerzyme Launches New Physician Exclusive Website | InnerzymeRX.com

A Natural Online Pharmacy Exclusively for Healthcare Practitioners.

Scottsdale, AZ, January 13, 2015-(PR.com) – Innerzyme is pleased to announce the launch of their new physician exclusive website www.innerzymeRX.com. The new site is a fully functional platform for healthcare practitioners to have the ability to recommend, carry and prescribe high quality, ethically created, nutritional supplements specially formulated by Innerzyme.

InnerzymeRX.com is designed to offer physicians an easy to use, safe and secure way to order Innerzyme supplements for their practice or conveniently drop-ship Innerzyme directly to a patient anywhere around the world. Each physician is assigned a unique login, which gives them access to physician pricing on all Innerzyme supplements (listed below) as well as the ability to order educational brochures, DVDs and product sample packets for patients.

Innerzyme Specialty Supplements Include:
Innerzyme Vitamin K2, MK-7, 300mcg (High Potency, Natural Vitamin K2 Supplement)
Innerzyme Pain & Inflammation Blend (Full Spectrum Systemic Enzyme Enhanced w/ Turmeric)
Innerzyme Papaya Enzyme Chewable (1,000,000 USP Units of Papain/Chewable)
Innerzyme Digestive Enzyme Complex (Full Range Digestive Enzyme Supplement)
Innerzyme Vitamin D3, 5000 IUs (Natural Form as cholecalciferol)

What are doctors saying about Innerzyme…
Dr. Eli Hammer, Medical Director of The Hammer Institute for Anti-Aging Medicine says, “of all the systemic enzyme brands on the market, I truly believe Innerzyme [Pain & Inflammation Blend] has finally optimized the proper enzyme blend, while also vastly improving upon the delivery system [enteric-coated tablets] for better efficacy and ease of administration. I can honestly say that Innerzyme is one of the best formulations around. In addition, I discovered Innerzyme Vitamin K2 MK-7 about two years ago and have been using this product exclusively ever since. Not only is it the only brand of Vitamin K2 that comes in a one capsule optimal dose of 300mcg, it is also of the MK-7 variety and produced naturally from fermented soybeans, the optimal source.”

Dr. Doron Kahana, Board Certified Pediatric Gastroenterologist says, “I honestly think Innerzyme’s
product [Digestive Enzyme Complex] is superior to most other enzymes available on the market. It is
natural, easy to administer, quick in onset and yields great results for patients with a large gamut of
clinical conditions, from indigestion and reflux, to bloating, gassiness and diarrhea.”

Innerzyme is revolutionizing the natural health and alternative medicine industry with their high potency,
specialized line of nutritional supplements, which are all made in the USA in a cGMP certified facility.

Join InnerzymeRX.com Today! If you are a licensed physician interested in carrying Innerzyme in your

PR.com Press Release Distribution Terms of Usepractice, please contact our customer service team by phone at (480) 284-8478 or email info@innerzyme.com to setup an account and take advantage of our physician exclusive offers through www.innerzymeRX.com. For more information about Innerzyme, visit www.innerzyme.com.

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Health Risks From Ibuprofen Use

Innerzyme Pain & Inflammation Blend, a Safe, Natural & Effective Alternative for Pain and Inflammation, Systemic Enzyme Formula

Before you take Ibuprofen again, you should know the health risks! http://well.blogs.nytimes.com/2012/12/05/for-athletes-risks-from-ibuprofen-use/?ref=health&_r=0

According to the article, “For Athletes, Risks From Ibuprofen Use” in The New York Times by Gretchen Reynolds, “many active people use the painkiller ibuprofen on an almost daily basis.” Whether an athlete is looking to kill the pain following a strenuous workout or thinking about preventative care from muscle soreness, it is clear that the risks of Ibuprofen are much higher than the benefits these athletes are hoping to experience.

Gretchen Reynolds states, “a valuable new study joins growing evidence that ibuprofen and similar anti-inflammatory painkillers taken before a workout do not offer any benefit and may be causing disagreeable physical damage instead, particularly to the intestines.” She later says, “the most common side-effect of ibuprofen is gastrointestinal damage.”

To read the full article: For Athletes, Risks From Ibuprofen Use by Gretchen Reynolds on December 5, 2012 (The New York Times)

Innerzyme Pain & Inflammation Blend offers a safe, natural, and effective alternative to reduce pain and inflammation following strenuous workouts or sports injuries without any harmful side effects.

Innerzyme’s proprietary blend contains Pancreatin, Papain, Bromelain, Trypsin, Chymotrypsin, Rutin, White Willow Bark and Turmeric root. It is specially formulated to naturally reduce pain, inflammation, excess fibrin and the buildup of excess free radicals.

P&I_FrontThe delivery system for Innerzyme’s Pain & Inflammation Blend is an enteric coated tablet. The enteric coating protects the enzymes from premature release in the acidic region of the stomach allowing maximum absorption and optimal release of the proprietary blend in the pancreatic juices. High potency, minimal dosage with maximum benefit! When taken on an empty stomach, it is believed that enzymes may help manage inflammation by supporting healthy blood flow to the irritated area.

Bromelain is most notable for its effectiveness in the reduction of inflammation and decreasing swelling, but the scope of its benefits continues to increase.* Derived from the pineapple fruit, this natural anti-inflammatory has many health benefits.

Chymotrypsin is naturally produced by the pancreas in the human body. The primary uses of chymotrypsin are as a naturally anti-inflammatory and as a digestive aid. As a natural anti-inflammatory, chymotrypsin may help reduce tissue damage and the formation of fibrin clots during inflammation.*

Turmeric is an herb, an Indian spice that has been used for many years because of its natural medicinal properties. Turmeric is rich in antioxidants and is a powerful anti-inflammatory.

Rutin is a potent bioflavonoid which are water-soluble plant pigments, naturally occurring chemical compounds important to maintaining optimal health. They support health by protecting and strengthening capillaries, help prevent bruising and provide support for many other biological functions.*

For more information about Innerzyme’s Pain & Inflammation Blend, visit: https://innerzyme.com//Systemic_Enzyme.html
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Studies Indicate that Vitamin K2 Protects Against Coronary Heart Disease

Innerzyme-Vitamin-K2Worldwide, cardiovascular diseases are the number one cause of death1, with over 7 million deaths each year attributed to the specific cardiovascular disease, coronary heart disease (CHD)2. CHD, the main cause of heart attacks3, results from atherosclerosis, the narrowing of the inside of the artery. The plaque that builds up within arteries results in decreased blood flow to the heart. This is comparable to your drain clogging after the pipes gradually collect gunk inside. The main risk factors for CHD are smoking, genetics, obesity, high blood pressure, diabetes, lack of exercise and stress4.

To combat coronary heart disease, doctors commonly utilize drugs and invasive procedures or surgeries5. In addition to, or in lieu of these sometimes-aggressive treatments, many employ lifestyle changes and take supplements to fight or prevent CHD. In order to determine specific risk factors related to cardiovascular diseases as well as others, a group of researchers in the Netherlands began an extensive population-based research effort called The Rotterdam Study6. Since 1989 the group has regularly interviewed and examined 15,000 elderly people within a specific district in the city of Rotterdam. With such a large number of localized subjects in this unique study, the scientists have the statistical power to determine whether or not specific risk factors are related to certain diseases. It is important to note that although these researchers can determine the relationship between risk and disease, they cannot determine whether a factor causes a disease or not.

In a seminal research paper generated by the Rotterdam Study, scientists and doctors determined that increased consumption of Vitamin K2 is correlated with a reduced risk of coronary heart disease7, building upon numerous studies describing the inhibitory effect of Vitamin K-dependent proteins on atherosclerosis. The Rotterdam researchers assessed the diet of nearly 8000 subjects using a validated semiquantitative food-frequency questionnaire conducted by trained dieticians. The concentration of Vitamin K2 and other micronutrients in common Dutch foods were determined using high-performance liquid chromatography, an analytical chemistry technique to separate, determine and quantify components of complex mixtures. Comprehensive clinical examinations were performed on all patients, including thorough blood work and assessment of atherosclerosis.

When the researchers assessed Vitamin K2 levels, they first noticed higher quantities in patients with greater total fat, saturated fat and calcium intake. Moreover they found higher levels in individuals with higher body mass index (body fat) and diabetes. Conversely they noticed lower Vitamin K2 levels in subjects with higher polyunsaturated fat (omega-3, omega-6, DHA, etc.). Furthermore, when analyzing cholesterol levels they found an inverse association with total cholesterol and a positive correlation with HDL (healthy cholesterol). Interestingly, Vitamin K2 intake was not correlated to a healthy lifestyle or diet, although some of the individual associations may suggest this.

Excitement arose when the researchers looked at the relationship between Vitamin K2 intake and coronary heart disease. To do this, they arranged patients into three evenly sized groups based on their Vitamin K2 levels (low, medium and high). When examining the high Vitamin K2 group the scientists discovered a strong and significant decrease in CHD incidence and CHD-related deaths.

Moreover there was a significant reduction in death from any cause in this group. In agreement with the coronary heart disease findings the researchers also found that patients with severe atherosclerosis had lower Vitamin K2. What is striking about these findings is that they still stand when the researchers adjusted for every other factor, including smoking, education, and diet. Additionally the researchers excluded subjects with previous heart attacks from their analysis in order to avoid a bias resulting from intentional changes in diet or lifestyle.

Altogether these data suggest that dietary intake of Vitamin K2 has a protective effect against coronary heart disease and death. Although this study does not prove Vitamin K2 specifically deters CHD, it provides additional support for a causal relationship between this dietary micronutrient and heart disease. Since this study was published, other groups have found similarly encouraging results. For instance, researchers discovered that for post-menopausal women, increased consumption of Vitamin K2 lowered the risk of atherosclerosis8. With the mounting evidence for Vitamin K2 reducing the risk of coronary heart disease the International Life Sciences Institute recently recommended taking Vitamin K29. Since it can be hard to consume the recommended amount of Vitamin K2 with a standard diet, taking a natural Vitamin K2 supplement, like Innerzyme Vitamin K2, MK-7, 300mcg can be advantageous. It will be exciting to learn more about the additional benefits of Vitamin K2 in the coming years, as it is an active area of research for many scientific and medical professionals.

References:

  1. “Global status report on noncommunicable diseases 2010” World Health Organization (2011).
  2. Lozano et al., “Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010” Lancet 380(9859): 2095–128 (2012).
  3. “Heart attack/coronary artery disease”. Mount Sinai Hospital, New York.
  4. “Causes”. Coronary artery disease. Mayo Foundation for Medical Education and Research (2012).
  5. Jameson et al., “Harrison’s principles of internal medicine” (16th ed.). New York: McGraw-Hill Medical Publishing Division (2005).
  6. Hofman et al., “Determinants of disease and disability in the elderly: the Rotterdam Elderly Study” European Journal of Epidemiology 7:403–422 (1991).
  7. Geleijnse et al., “Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study” Journal of Nutrition 134(11):3100-3105 (2004).
  8. Beulens et al., “High dietary menaquinone intake is associated with reduced coronary calcification” Atherosclerosis 203(2):489-93 (2009).
  9. Beulens et al., “The role of menaquinones (vitamin K₂) in human health” Journal of Nutrition 110(8):1357-68 (2013).
About the Author:

Katie Jodscheidt is a Fitness Nutrition Specialist and Certified Personal Trainer through the National Academy of Sports Medicine (NASM).

Katie is passionate about helping others improve their overall quality of life by improving their health. Her mission is to educate people on how to live a healthy lifestyle through proper diet, exercise and nutritional supplementation. With years of research on natural health alternatives and collaborating with highly trained physicians around the world, Katie Jodscheidt founded Innerzyme in 2011. Innerzyme is revolutionizing the natural health industry with specially formulated, ethically created nutritional supplements including Vitamin K2, MK-7, 300mcg and a full range of digestive and systemic enzyme supplements. All Innerzyme supplements are made in the USA in a cGMP certified facility.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Improving Your Overall Health With Enzyme Therapy

Improving your overall health starts with being health conscious, making smart lifestyle choices and focusing on preventative care. Today’s fast-paced world has created a mindset of instant gratification even when health is involved. People want to take a pill and instantly feel a difference, and many do not see value in preventative therapies unless they see a problem first. With poor lifestyle choices today consisting of fad diets, eating processed foods, taking prescription medication, consuming alcohol, over indulging in sweets and artificial sweeteners, the body is working in overdrive to rid itself of toxins and reduce body-wide inflammation. If more time was spent focusing on natural alternatives to prevent illness rather than reacting to illness and treating with prescription drugs, the world would be a healthier place.

The truth is, most people are not aware how good their body is actually designed to feel. This is where enzyme therapy comes into play. For most healthy individuals, our bodies naturally produce an optimal amount of enzymes until we reach our mid- to late-twenties. As we know, some people in their forties may be healthier than someone in their twenties. This can be a result of lifestyle choices, which can effect enzyme production from person to person.

So what are enzymes and why are they vital to your health? Enzymes are biocatalysts or proteins necessary for nearly 3000-4000 of the chemical reactions within our body that are associated with metabolic functions, digestion, detoxification, healthy immune system functioning, growth and natural healing. What does this ultimately mean? It means enzymes help other things work throughout the body. People over the age of 30 have an increased likelihood of enzyme deficiency, which may lead to greater chances of health issues and illnesses (5).

When people think of enzymes, they most often think digestion. However, there are two different types of enzymes: digestive enzymes and systemic enzymes. Digestive enzymes are taken with a meal and help support overall digestive health by breaking down the food a person eats while also helping to improve nutrient absorption.

Many people are enzyme deficient and do not even know it. According to the National Institute of Health, “60 to 70 million people in America suffer from some type of digestive disorder. People who suffer from poor digestive health are commonly linked to low energy, excessive gas, poor skin health, joint pain, inflammation, weight-gain, weak immune system, heartburn and bloating following meals” (9). Whether a person is looking to improve their digestive health or may be avoiding certain foods that commonly aggravate the gastrointestinal tract, implementing a well-balanced digestive enzyme complex ensure the body is properly breaking down fats, carbohydrates, proteins into small substrates that can be utilized for energy production throughout the day.

Much different than the role of a digestive enzyme is a systemic enzyme. Systemic enzymes work to support the body as a whole. They are most notably knows for their five main functions: natural anti-inflammatory, anti-fibrin, blood cleansing, immune system modulating and virus fighting. When considering a systemic enzyme supplement, it is important to look at the proprietary blend and delivery system. In order to ensure maximum absorption of activity, an enteric-coated delivery system is ideal which will protect the enzyme activity until the optimal time of release. The enteric-coated delivery system allows it to get past the stomach and into the small intestine without losing enzyme activity, which allows for better absorption.

Proteolytic enzymes or “protein eating enzymes” are the first line of defense against body wide inflammation, which may spread throughout the body to all major organs. Inflammation is a reaction by the immune system to an irritation which often results in pain, swelling or tenderness. Conventional medicine still tends to use pharmaceutical drugs such as ibuprofen and naproxen to reduce inflammation. However, synthetic drugs have many side effects, both minor and severe, that often hinder long-term use in many people. A well-balanced Systemic Enzyme blend will naturally replenish the many enzymes the body uses to fight inflammation and aid in the repair of damaged tissue (1,3,4,6,8).

Did you know that nearly all injuries and operations result in inflammatory reactions and build up of excess scar tissue which causes pain and swelling? It is a natural protective response to injuries and trauma on a cellular level. However, if the inflammation is not resolved ore reduced in the acute stage, it can become a chronic inflammatory problem (1,4,6). When caring for injuries and during recovery following an operation, “it is important to apply medications for reducing the swelling and anti-inflammatory as well as fibrinolytic agents. If possible, such treatment should produce no adverse effects and should further the healing process of the organism” (10). A safe and effective Systemic Enzyme formula, like Innerzyme’s Pain & Inflammation Blend, offers a natural solution for post-operative scar tissue, inflammation, and pain following sports injuries and surgery whether recent or fifteen plus years ago.

In addition to it’s anti-fibrin properties, systemic enzymes are also known for their ability to cleanse the blood of excess fibrin and exogenous material. Cleaner blood means better nutrient absorption and improved circulation. So how do these toxins and fibrin get into the blood in the first place? The organs and cells in our bodies dispose of these materials in our blood, which can cause clots, poor circulation, blood thickening and other health issues (2).

How about immune system support and the ability to fight off viruses? Systemic enzymes assist the body to balance the immune system and restore a steady state to the body. A low functioning immune system means the body is more susceptible to disease. However, an extremely high functioning immune system will often create antibodies that attach the tissues within the body such as with autoimmune diseases or arthritis. Supplementation of a well-balanced systemic enzyme may help regulate the immune system and eat away at those antibodies that are attacking the body’s tissue creating a disease state within the body (7).

When it comes to viruses, protein cell walls build up around a virus and then bond together and replicate to cause harm throughout the body. The body knows what the body needs and these harmful protein walls are definitely not needed. The good thing about enzymes is they already know what protein to leave alone and what “foreign” protein to attack and eat away in order to inhibit the replication of the virus (7).

Dr. Eli Hammer, Medical Director of The Hammer Institute for Anti-Aging Medicine, states, “I have used systemic enzymes extensively in my practice along with taking them personally for a few years, seeing dramatic reductions in pain and inflammation, and therefore, significant improvements in quality of life. Of all the systemic enzyme brands on the market, I truly believe Innerzyme has finally optimized the proper enzyme blend, while also vastly improving upon the delivery system for better efficacy and ease of administration” (3).

Someone who lives a healthy lifestyle comprised of a balanced diet, regular exercise and proper nutritional supplementation will ultimately help their body to maintain wellness and regulate efficiently.

Learn more about the benefits of enzyme therapy with Innerzyme, click here!

References:

  1. Beth Kapes, Bromelain Health Article. The Gale Group Inc., Gale, Detroit, 2005. Online.
  2. Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994. 9)
  3. Hammer, Eli J., MD. “Benefits of Enzyme Therapy, Innerzyme & Anti-Aging.” Personal interview. 10 May 2012.
  4. Hoemecke R, Doenicke A. Perioperative enzyme therapy. A significant supplement to postoperative pain therapy? Anaesthesist. 1993 Dec;42(12):856-61.
  5. Howell, Edward, and Maynard Murray. Enzyme Nutrition: The Food Enzyme Concept. Wayne, NJ: Avery Pub. Group, 1985. Print.
  6. Judith Sims, Rebecca J. Frey PhD, Chymotrypsin Health Article. The Gale Group Inc., Gale, Detroit, 2005. Online.
  7. Kunze R., Ransberger K., et at: Humoral immunomodulatory capasity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991.
  8. Miller. Proteolytic enzymes in inflammation: rationale for use. Postgrad Med. 1956 Jan;19(1):16-22.
  9. National Institutes of Health, U.S. Department of Health and Human Services. Opportunities and Challenges in Digestive Diseases Research: Recommendations of the National Commission on Digestive Diseases. Bethesda, MD: National Institutes of Health; 2009. NIH Publication 08–6514. http://www.nih.gov/
  10. Wrba, H. & Pecher, O. Enzymes: A Drug of the Future. Ecomed Verlagsgesellschaft AG & Co., 1993. Print.

Check out these other great educational resources!

Can Enzyme Deficiency Make You Tired?
Sirah Dubois, July 27, 2011. LIVESTRONG.COM

Laboratory Study Shows Turmeric May Have Bone-Protective Effects
National Center for Complementary and Alternative Medicine, September 8, 2010

Evidence in Mice May Spur More Research on Fish Oil and Curcumin for Alzheimer’s Disease
National Center for Complementary and Alternative Medicine, July 15, 2009

Researchers Investigate Anti-Inflammatory Effects of Pineapple Extracts
National Center for Complementary and Alternative Medicine, August 1, 2006

Your Vitamin-D Level, Part I: How’s Your Mood?
Margaret Furtado, M.S., R.D., November 16, 2011

Bromelain Health Article
Beth Kapes, The Gale Group., Gale, Detroit, 2005

Enzymes For Ulcerative Colitis
Jean Bardot, Livestrong.com, August 11, 2011


Turmeric for Depression
Andrew Weil, M.D., 2011

Turmeric-Natural Medicinal Properties
Joan Schonbeck, Rebecca J. Frey PhD, The Gale Group Inc., Gale, Detroit, 2005

White Willow Health Article
Jennifer Wurges, Rebecca J. Frey PhD, The Gale Group Inc., Gale, Detroit, 2005

Chymotrypsin Health Article
Judith Sims, Rebecca J. Frey PhD, The Gale Group Inc., Gale, Detroit, 2005

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High Profile Studies of Vitamin K2 Provide Hope for Parkinson’s Patients

Parkinson’s disease (PD) is a common neurodegenerative disorder affecting the central nervous
system. This devastating disease affects part of the brain associated with critical functions, such as vision, hearing and movement (1). With an absence of definitive markers for Parkinson’s, diagnosis is made on a clinical basis. With 60,000 new cases every year in the U.S. there are nearly one million American’s living with PD, costing an astounding $25 billion per year (2). The most obvious symptoms of PD are shaking, rigidity and slow movement, exemplified by the famous PD patient, actor Michael J. Fox (3). The symptoms are a result of the death of a specific type of cell in the aforementioned midbrain that produces dopamine, resulting in lower levels of this neurotransmitter that is crucial for regulation of movement and other functions.

For many patients there are no definitive causes or risk factors for Parkinson’s disease, most likely being triggered by a combination of genetic and environmental factors (mix of nature and nurture). On the other hand, some PD cases are attributed to mutations in specific genes (4). These mutations have adverse effects on the function of the proteins in which they code for, resulting in significant biological defects. One such Parkinson’s gene is PINK1 (5,6,7). PINK1 functions in “powerhouse” of the cell, the mitochondria, and is involved with neuron differentiation (8).

A study from the laboratory of Patrik Verstreken published in the prestigious journal Science describes an exciting discovery in relation to Parkinson’s-related PINK1 deficiency (I9). Specifically, they discovered that vitamin K2 alleviates the negative effects of the Parkinson’s specific PINK1 mutations in fruit flies. Flies are one the most prevalently used organisms in genetic and biological studies. Their utility lies within their ease of use, as well as the fact that the inner workings and cellular activities of these little animals reflect what occurs within our cells. Conservation of machinery and processes between flies and humans results in the majority of scientific discoveries in flies holding true for humans as well.

The Verstreken lab discovered the connection between PINK1 and vitamin K2 by beginning their experiments with a poor flying PINK1 mutant fly. Subsequently, they selectively looked for additional mutations in the flies that resulted in poorer flight ability. The rationale behind this standard genetic approach was to find genes that were involved in the same processes as PINK1, with the hypothesis that a poorer flying mutant would have a mutation in something related to PINK1’s role in flight. They found that the worst flying double mutant had an additional mutation in the HEIX gene, which is involved in vitamin K2 synthesis in bacteria and humans.

With the data suggesting that vitamin K2 is involved with PINK1 in flight, they asked whether feeding PINK1 mutant fruit flies vitamin K2 could alleviate their poor flight, as well as other symptoms. Amazingly, PINK deficient flies fed vitamin K2 had significantly improved flight, energy levels, and survival rates compared to flies not supplemented with vitamin K2. Encouragingly, the observed improvements with vitamin K2 were dose-dependent and time-dependent, characteristic of prototypical drugs and supplements. Further experiments demonstrated that the improvements were most likely due to improved mitochondria function, meaning more efficient energy production. Digging even deeper, the researchers discovered that vitamin K2 could transport electrons, an essential step in energy production.

Altogether the experimental results described in this paper constitute a significant leap in our scientific understanding of the potential of vitamin K2, as well as encouraging news for those suffering from Parkinson’s. Since the publication of the Verstreken lab’s findings researchers have found that vitamin K2 synthesis is also crucial for embryonic and vascular development (10,11). Adding to the encouragement is the fact that vitamin K2 is a natural form of vitamin K. These new discoveries, as well as the general nature of vitamin K2’s improvement of energy production provide ample support for the idea that vitamin K2 can help people suffering from other diseases and disorders, as well as a general supplement to improve overall health and well-being.

References:

  1. Breedlove et. al., Biological Psychology, 6th Edition, 2010.
  2. http://www.pdf.org/en/parkinson_statistics.
  3. Brockes, “It’s the gift that keeps on taking”. The Guardian, 11 April 2009.
  4. Nuytemans et. al.,; “Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update”, Human Mutation 31 (7): 763–780 (2010).
  5. Valente et. al., (2004). “Hereditary early-onset Parkinson’s disease caused by mutations in PINK1”, Science 304 (5674): 1158–60 (2014).
    Pimenta de Castro et. al., “Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster”, Cell Death and Differentiation 19 (8): 1308–16 (2012).
  6. Valente et. al., “PINK1 mutations are associated with sporadic early-onset parkinsonism”, Annals of Neurology 56 (3): 336–41 (2004).
    Dagda et. al., “Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A”, Journal of Neurochemistry 128(6):864-77 (2014).
  7. M. Vos et. al., “Vitamin K2 is a mitochondrial electron carrier that rescues PINK1 deficiency”, Science 336(6086):1306-10 (2012).
    Nakagawa et. al., “Vitamin K2 biosynthetic enzyme, UBIAD1 is essential for embryonic development of mice” PLOS One. Aug 15;9(8):e104078 (2014).
  8. Hegarty et. al., “UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development” Development. 140(8):1713-9 (2013).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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Innerzyme Receives 2013 Best of Scottsdale Award

SCOTTSDALE – Innerzyme has been selected for the 2013 Best of Scottsdale Award in the Vitamins category by the Scottsdale Award Program.

Each year, the Scottsdale Award Program identifies companies that we believe have achieved exceptional marketing success in their local community and business category. These are local companies that enhance the positive image of small business through service to their customers and our community. These exceptional companies help make the Scottsdale area a great place to live, work and play.

Various sources of information were gathered and analyzed to choose the winners in each category. The 2013 Scottsdale Award Program focuses on quality, not quantity. Winners are determined based on the information gathered both internally by the Scottsdale Award Program and data provided by third parties.

About Scottsdale Award Program

The Scottsdale Award Program is an annual awards program honoring the achievements and accomplishments of local businesses throughout the Scottsdale area. Recognition is given to those companies that have shown the ability to use their best practices and implemented programs to generate competitive advantages and long-term value.

The Scottsdale Award Program was established to recognize the best of local businesses in our community. Our organization works exclusively with local business owners, trade groups, professional associations and other business advertising and marketing groups. Our mission is to recognize the small business community’s contributions to the U.S. economy.

SOURCE: Scottsdale Award Program

CONTACT:
Scottsdale Award Program
Email: PublicRelations@awardprogram.org
URL: http://www.awardprogram.org

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Innerzyme Launces Highest Potency Non-GMO Natural Vitamin K2, MK-7, 300 mcg Supplement

Scottsdale, AZ – Innerzyme, a highly reputable and fast growing nutraceutical company specializing in natural digestive and systemic enzyme supplements has launched the highest potency, Non-GMO Vitamin K2, MK-7 supplement on the market which provides 300 mcg in a single vegetarian capsule. Innerzyme utilizes a pure, optimum quality Vitamin K2, MK-7 as menaquinone-7 from Non-GMO fermented soybeans.

The decision to formulate and launch a high potency Vitamin K2, MK-7, 300mcg supplement came after much research into health and dietary habits of Eastern cultures and collaboration with a strategic team of healthcare professionals who focus primarily on preventative care through alternative medicine.

Vitamin K has long been recognized for its role in protein biosynthesis for the blood coagulation process. However, research now indicates that Vitamin K plays a vital part in a variety of complex physiological functions within the body. More specifically, studies show high doses of Vitamin K2, MK-7, the menaquinones, may help promote cardiovascular, bone and soft tissue health.* (1,3)

The K group of vitamins includes Vitamin K1 and Vitamin K2. It is important to know that Vitamin K1 and Vitamin K2 not only come from different sources but also have different functions. Vitamin K1 is readily available in plant-based foods and easy to consume. The best way to get an adequate amount of Vitamin K1 is through your diet. Vitamin K1 offers adequate blood clotting support, however, there are a variety of health related issues that Vitamin K1 does not sufficiently support.* (2) Studies show these growing health issues are better addressed by Vitamin K2 in the natural form of MK-7. Although many people in Eastern cultures consume fermented soybeans, the slimy and smelly taste and texture of them often make it too harsh and unpleasant to consume.

With the growing research on the many health benefits associated with Vitamin K2, MK-7, Innerzyme wanted to offer an easier and more convenient way for people to get an adequate amount of MK-7. This new addition to the Innerzyme line of natural supplements has done just that with an easy to swallow, one a day vegetarian capsule providing 300 mcg of Vitamin K2, MK-7.

Vitamin K2, MK-7 may support:

  • Cardiovascular Health*
  • Bone and Soft Tissue Health*
  • Arterial Calcification*
  • Healthy Brain Function*

In healthy individuals, research has not reported any side effects, adverse reactions or known toxicity as a result of large doses of Vitamin K2. However, individuals on anticoagulants such as warfarin should consult their healthcare professional before adding a Vitamin K2 supplement to their daily regimen.

Innerzyme is dedicated to improving the overall quality of life for people by spreading awareness about the importance of preventative health and living a healthy lifestyle through proper diet, exercise and nutritional supplementation. Innerzyme is committed to providing people with safe, natural and effective products. Innerzyme supplements are manufactured in the USA to the highest standards in a cGMP certified facility.

For more information about Innerzyme Vitamin K2, MK-7:

Website: http://www.optimumvitamink2.com
Phone: (480) 284-8478
Email: info@innerzyme.com

**Warning: If you have a health condition, are pregnant, nursing, lactating, trying to become pregnant or taking any medications (especially anticoagulants such as warfarin), consult your healthcare practitioner before using this product.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

  1. Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009;203:489-493.
  2. Booth SL, Suttie JW. Dietary intake and adequacy of vitamin K. J Nutr. 1998;128(5):785-788.
  3. Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004;134(11):3100-5.
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